Literature summary for 5.6.2.1 extracted from

Laco, G.S.
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives (2011), PLoS ONE, 6, e24314.

Search for more literature for 5.6.2.1

Application

Application	Comment	Organism
medicine	the enzyme is an anti-cancer target	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
10-Hydroxycamptothecin	camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death. Structure-activity-relationships for camptothecin and derivatives, modeling and calculation of interaction energies between bound camptothecin, and derivatives, and Top1/dsDNA, comparisons of different models, e.g. rotated +1 nucleoside and intercalated models, overview	Homo sapiens
camptothecin	camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death. Structure-activity-relationships for camptothecin and derivatives, modeling and calculation of interaction energies between bound camptothecin, and derivatives, and Top1/dsDNA, comparisons of different models, e.g. rotated +1 nucleoside and intercalated models, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Top1	-	Homo sapiens
Topoisomerase I	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	topoisomerase I relaxes supercoiled DNA during cell division	Homo sapiens

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Release 2023.1 (January 2023)