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Literature summary for 5.6.2.1 extracted from

  • Valenti, A.; Perugino, G.; Varriale, A.; D'Auria, S.; Rossi, M.; Ciaramella, M.
    The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions (2010), J. Biol. Chem., 285, 36532-36541.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
supercoiled DNA Saccharolobus solfataricus reverse gyrase induces unwinding of synthetic four-way junctions as well as forked DNA substrates, following a mechanism independent of both the ATPase and the strand cutting activity of the enzyme. Reverse gyrase works like an ATP-independent helix-destabilizing protein specific for branched DNA structures ?
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supercoiled DNA Saccharolobus solfataricus P2 reverse gyrase induces unwinding of synthetic four-way junctions as well as forked DNA substrates, following a mechanism independent of both the ATPase and the strand cutting activity of the enzyme. Reverse gyrase works like an ATP-independent helix-destabilizing protein specific for branched DNA structures ?
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Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
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Saccharolobus solfataricus P2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA reverse gyrase induces unwinding of synthetic four-way junctions as well as forked DNA substrates, following a mechanism independent of both the ATPase and the strand cutting activity of the enzyme. Reverse gyrase works like an ATP-independent helix-destabilizing protein specific for branched DNA structures Saccharolobus solfataricus ?
-
 ?
supercoiled DNA reverse gyrase induces unwinding of synthetic four-way junctions as well as forked DNA substrates, following a mechanism independent of both the ATPase and the strand cutting activity of the enzyme. Reverse gyrase works like an ATP-independent helix-destabilizing protein specific for branched DNA structures Saccharolobus solfataricus P2 ?
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 ?

Synonyms

Synonyms Comment Organism
Reverse gyrase is a DNA topoisomerase, specific to microorganisms living at high temperatures, which comprises a type IA topoisomerase fused to an SF2 helicase-like module and catalyzes ATP hydrolysis-dependent DNA positive supercoiling Saccharolobus solfataricus
TopR1
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 Saccharolobus solfataricus

General Information

General Information Comment Organism
physiological function reverse gyrase is a DNA topoisomerase, specific to microorganisms living at high temperatures, which comprises a type IA topoisomerase fused to an SF2 helicase-like module and catalyzes ATP hydrolysis-dependent DNA positive supercoiling. Reverse gyrase is likely involved in regulation of DNA structure and stability and might also participate in the cell response to DNA damage Saccharolobus solfataricus