Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3'-(4-phenylpyridine-2,6-diyl)diphenol | 67.2% inhibition at 0.1 mM | Homo sapiens | |
3-(2,6-diphenylpyridin-4-yl)phenol | 11.5% inhibition at 0.1 mM | Homo sapiens | |
3-(4,6-diphenylpyridin-2-yl)phenol | 12.9% inhibition at 0.1 mM | Homo sapiens | |
3-(4-phenyl-2,4'-bipyridin-6-yl)phenol | 70.4% inhibition at 0.1 mM | Homo sapiens | |
3-(6-phenyl-2,2'-bipyridin-4-yl)phenol | 10.8% inhibition at 0.1 mM | Homo sapiens | |
3-(6-phenyl-2,3'-bipyridin-4-yl)phenol | 8.8% inhibition at 0.1 mM | Homo sapiens | |
3-(6-phenyl-2,4'-bipyridin-4-yl)phenol | 60.8% inhibition at 0.1 mM | Homo sapiens | |
3-[2-(furan-2-yl)-6-phenylpyridin-4-yl]phenol | 48.8% inhibition at 0.1 mM | Homo sapiens | |
3-[2-phenyl-6-(thiophen-2-yl)pyridin-4-yl]phenol | 9.1% inhibition at 0.1 mM | Homo sapiens | |
3-[2-phenyl-6-(thiophen-3-yl)pyridin-4-yl]phenol | 6.9% inhibition at 0.1 mM | Homo sapiens | |
3-[4-phenyl-6-(thiophen-2-yl)pyridin-2-yl]phenol | 51.2% inhibition at 0.1 mM | Homo sapiens | |
3-[4-phenyl-6-(thiophen-3-yl)pyridin-2-yl]phenol | 75.8% inhibition at 0.1 mM | Homo sapiens | |
3-[6-(furan-2-yl)-4-phenylpyridin-2-yl]phenol | 10.2% inhibition at 0.1 mM | Homo sapiens | |
4-(4,6-diphenylpyridin-2-yl)phenol | 52.9% inhibition at 0.1 mM | Homo sapiens | |
4-(4-phenyl-2,3'-bipyridin-6-yl)phenol | 44% inhibition at 0.1 mM | Homo sapiens | |
4-(6-phenyl-2,4'-bipyridin-4-yl)phenol | 57.5% inhibition at 0.1 mM | Homo sapiens | |
4-[2-(furan-2-yl)-6-phenylpyridin-4-yl]phenol | 5.0% inhibition at 0.1 mM | Homo sapiens | |
4-[4-phenyl-6-(thiophen-2-yl)pyridin-2-yl]phenol | 4.9% inhibition at 0.1 mM | Homo sapiens | |
4-[4-phenyl-6-(thiophen-3-yl)pyridin-2-yl]phenol | 20.4% inhibition at 0.1 mM | Homo sapiens | |
4-[6-(furan-2-yl)-4-phenylpyridin-2-yl]phenol | 18.6% inhibition at 0.1 mM | Homo sapiens | |
camptothecin | - |
Homo sapiens | |
additional information | inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines, overview. Hydroxyl substitution at 3- or 3'-position of phenyl ring on 2,4-diphenyl-6-aryl pyridines might be required in order to show significant topo inhibitory activity. No inhibition by 15, 35, and 31 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant topoisomerase I | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | relaxation of supercoiled pBR322 plasmid DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Homo sapiens |