Inhibitors | Comment | Organism | Structure |
---|---|---|---|
irinotecan | topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Rattus norvegicus | - |
colonic mucosa | - |
Rattus norvegicus | - |
duodenum | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
mucosa | - |
Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Rattus norvegicus |