Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nick-containing oligonucleotides | inhibit DNA substrate relaxation. Synthesis of and enzyme inhibition by a series of oligonucleotides with various lengths that contain nick and topoisomerase I-binding sites, sequences, overview. The position of the nick as well as the length of the oligonucleotides are crucial factors for the inhibition of the nuclear enzyme | Homo sapiens | |
nick-containing oligonucleotides s | inhibit DNA substrate relaxation. Synthesis of and enzyme inhibition by a series of oligonucleotides with various lengths that contain nick and topoisomerase I-binding sites, sequences, overview. The position of the nick as well as the length of the oligonucleotides are crucial factors for the inhibition of the nuclear enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate is supercoiled pBR322 DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000063 | - |
- |
Homo sapiens | nick-containing oligonucleotides | |
0.0000063 | - |
- |
Homo sapiens | nick-containing oligonucleotide |