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Literature summary for 5.6.2.1 extracted from
- Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants (2008), Proc. Natl. Acad. Sci. USA, 105, 6782-6786.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| D-galactose | - |
Ophiorrhiza pumila |  |
| D-galactose | - |
Camptotheca acuminata | |
| D-galactose | - |
Homo sapiens | |
| D-galactose | - |
Ophiorrhiza liukiuensis | |
| D-galactose | - |
Ophiorrhiza japonica | |
| D-galactose | - |
Arabidopsis thaliana | |
| D-glucose | - |
Ophiorrhiza pumila | |
| D-glucose | - |
Camptotheca acuminata | |
| D-glucose | - |
Homo sapiens | |
| D-glucose | - |
Ophiorrhiza liukiuensis | |
| D-glucose | - |
Ophiorrhiza japonica | |
| D-glucose | - |
Arabidopsis thaliana | |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Catharanthus roseus |
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza pumila |
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Camptotheca acuminata |
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza liukiuensis |
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza japonica |
| drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Arabidopsis thaliana |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae | Catharanthus roseus |
| expressed in Saccharomyces cerevisiae | Ophiorrhiza japonica |
| expressed in Saccharomyces cerevisiae | Arabidopsis thaliana |
| heterologously expressed in Escherichia coli exhibits topoisomerase activity | Ophiorrhiza pumila |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| I420V | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
| L530I | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
| N421K | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
| N722S | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| camptothecin | - |
Arabidopsis thaliana | |
| camptothecin | - |
Camptotheca acuminata | |
| camptothecin | - |
Catharanthus roseus | |
| camptothecin | - |
Homo sapiens | |
| camptothecin | - |
Ophiorrhiza japonica | |
| camptothecin | - |
Ophiorrhiza liukiuensis | |
| camptothecin | - |
Ophiorrhiza pumila | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | P30181 | - |
- |
| Camptotheca acuminata | - |
camptothecin producing plant | - |
| Catharanthus roseus | - |
camptothecin non producing plant | - |
| Homo sapiens | P11387 | - |
- |
| Ophiorrhiza japonica | - |
camptothecin non producing plant | - |
| Ophiorrhiza liukiuensis | - |
camptothecin producing plant has Top1s with point mutations that confer resistance to camptothecin, suggesting the effect of an endogenous toxic metabolite on the evolution of the target cellular component | - |
| Ophiorrhiza pumila | - |
camptothecin producing plant | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hairy root | - |
Ophiorrhiza pumila | - |
| hairy root | - |
Ophiorrhiza liukiuensis | - |
| leaf | young | Catharanthus roseus | - |
| leaf | young | Camptotheca acuminata | - |
| leaf | young | Ophiorrhiza japonica | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AtTop1 | - |
Arabidopsis thaliana |
| Ca-Top1 | - |
Camptotheca acuminata |
| CrTop1 | - |
Catharanthus roseus |
| HsTop1 | - |
Homo sapiens |
| human Top1 | - |
Homo sapiens |
| OjTop1 | - |
Ophiorrhiza japonica |
| OlTop1 | - |
Ophiorrhiza liukiuensis |
| OpTop1 | - |
Ophiorrhiza pumila |
| Top1 | - |
Catharanthus roseus |
| Top1 | - |
Ophiorrhiza pumila |
| Top1 | - |
Camptotheca acuminata |
| Top1 | - |
Homo sapiens |
| Top1 | - |
Ophiorrhiza liukiuensis |
| Top1 | - |
Ophiorrhiza japonica |
| Top1 | - |
Arabidopsis thaliana |
| Topoisomerase I | - |
Catharanthus roseus |
| Topoisomerase I | - |
Ophiorrhiza pumila |
| Topoisomerase I | - |
Camptotheca acuminata |
| Topoisomerase I | - |
Homo sapiens |
| Topoisomerase I | - |
Ophiorrhiza liukiuensis |
| Topoisomerase I | - |
Ophiorrhiza japonica |
| Topoisomerase I | - |
Arabidopsis thaliana |
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