Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae strain EKY3 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T729A | mutations that confer camptothecin resistance, but do not interact directly with the drug or the DNA, oligonucleotide-directed mutagenesis | Homo sapiens |
T729E | camptothecin resistance, remarkable defect in DNA binding, oligonucleotide-directed mutagenesis | Homo sapiens |
T729K | camptothecin resistance, oligonucleotide-directed mutagenesis | Homo sapiens |
T729P | oligonucleotide-directed mutagenesis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
camptothecin | - |
Homo sapiens | |
topotecan | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
phosphocellulose chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
negatively supercoiled DNA | - |
Homo sapiens | relaxed DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hTop1p | - |
Homo sapiens |
human DNA topoisomerase I | - |
Homo sapiens |