Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.1 extracted from

  • Diana, P.; Martorana, A.; Barraja, P.; Montalbano, A.; Dattolo, G.; Cirrincione, G.; Dallacqua, F.; Salvador, A.; Vedaldi, D.; Basso, G.; Viola, G.
    Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I (2008), J. Med. Chem., 51, 2387-2399.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
2,3-dichloro-5H-isoindolo[2,1-a]quinoxalin-6-one
-
 Homo sapiens
2,3-dimethyl-5H-isoindolo[2,1-a]quinoxalin-6-one
-
 Homo sapiens
3-methoxy-5H-isoindolo[2,1-a]quinoxalin-6-one
-
 Homo sapiens
4-methyl-5H-isoindolo[2,1-a]quinoxalin-6-one
-
 Homo sapiens
additional information determination for every cell line: GI50 (concentration inhibiting 50% net cell growth), TGI (total growth inhibition), and LC50 (concentration leading to 50% net cell death) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-498 cell renal cancer cell line Homo sapiens
-
A-549 cell nonsmall cell lung cancer cell line Homo sapiens
-
ACHN cell renal cancer cell line Homo sapiens
-
BT-549 cell breast cancer cell line Homo sapiens
-
Caki-1 cell renal cancer cell line Homo sapiens
-
CCRF-CEM cell leukemia cell line Homo sapiens
-
Colo-205 cell colon cancer cell line Homo sapiens
-
DU-145 cell prostate cancer cell line Homo sapiens
-
EKVX cell nonsmall cell lung cancer cell line Homo sapiens
-
HCC-2998 cell colon cancer cell line Homo sapiens
-
HCT-116 cell colon cancer cell line Homo sapiens
-
HCT-15 cell colon cancer cell line Homo sapiens
-
HL-60 (TB) cell leukemia cell line Homo sapiens
-
HOP-62 cell nonsmall cell lung cancer cell line Homo sapiens
-
HOP-92 cell nonsmall cell lung cancer cell line Homo sapiens
-
Hs-578T cell breast cancer cell line Homo sapiens
-
HT-29 cell colon cancer cell line Homo sapiens
-
IGROV-1 cell ovarian cancer cell line Homo sapiens
-
K-562 cell leukemia cell line Homo sapiens
-
KM-12 cell colon cancer cell line Homo sapiens
-
LOX-IMVI cell melanoma cancer cell line Homo sapiens
-
M14 cell melanoma cancer cell line Homo sapiens
-
MALME-3M cell melanoma cancer cell line Homo sapiens
-
MCF-7 cell breast cancer cell line Homo sapiens
-
MDA-MB-231 cell breast cancer cell line Homo sapiens
-
MDA-MB-435 cell breast cancer cell line Homo sapiens
-
MOLT-4 cell leukemia cell line Homo sapiens
-
NCI-H226 cell nonsmall cell lung cancer cell line Homo sapiens
-
NCI-H23 cell nonsmall cell lung cancer cell line Homo sapiens
-
NCI-H322M cell nonsmall cell lung cancer cell line Homo sapiens
-
NCI-H460 cell nonsmall cell lung cancer cell line Homo sapiens
-
NCI-H522 cell nonsmall cell lung cancer cell line Homo sapiens
-
NCI/ADR-RES cell breast cancer cell line Homo sapiens
-
OVCAR-3 cell ovarian cancer cell line Homo sapiens
-
OVCAR-4 cell ovarian cancer cell line Homo sapiens
-
OVCAR-5 cell ovarian cancer cell line Homo sapiens
-
OVCAR-8 cell ovarian cancer cell line Homo sapiens
-
PC-3 cell prostate cancer cell line Homo sapiens
-
RCC 786-O cell renal cancer cell line Homo sapiens
-
RPMI-8226 cell leukemia cell line Homo sapiens
-
RXF-393 cell renal cancer cell line Homo sapiens
-
SF-268 cell CNS cancer cell line Homo sapiens
-
SF-295 cell CNS cancercell line Homo sapiens
-
SF-539 cell CNS cancer cell line Homo sapiens
-
SK-MEL-2 cell melanoma cancer cell line Homo sapiens
-
SK-MEL-28 cell melanoma cancer cell line Homo sapiens
-
SK-MEL-5 cell melanoma cancer cell line Homo sapiens
-
SKOV-3 cell ovarian cancer cell line Homo sapiens
-
SN-12C cell renal cancer cell line Homo sapiens
-
SNB-19 cell CNS cancer cell line Homo sapiens
-
SNB-75 cell CNS cancer cell line Homo sapiens
-
SR cell leukemia cell line Homo sapiens
-
SW-620 cell colon cancer cell line Homo sapiens
-
T-47D cell breast cancer cell line Homo sapiens
-
TK-10 cell renal cancer cell line Homo sapiens
-
U-251 cell CNS cancer cell line Homo sapiens
-
UACC-257 cell melanoma cancer cell line Homo sapiens
-
UACC-62 cell melanoma cancer cell line Homo sapiens
-
UO-31 cell renal cancer cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topoisomerase I
-
 Homo sapiens