Literature summary for 5.6.2.1 extracted from

Gul, H.I.; Cizmecioglu, M.; Zencir, S.; Gul, M.; Canturk, P.; Atalay, M.; Topcu, Z.
Cytotoxic activity of 4-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I (2009), J. Enzyme Inhib. Med. Chem., 24, 804-807.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-2-propen-1-one	chalcones (1,3-diaryl-2-propen-1-ones) are alpha, beta-unsaturated ketones with cytotoxic and anticancer properties. Compound has the highest Hammett and log P values (0.23 and 4.21, respectively) and exerted both highest cytotoxicity and strongest DNA topoisomerase I inhibition	Homo sapiens
3-(4-methylphenyl)-1-(4'-hydroxyphenyl)-2-propen-1-one	chalcones (1,3-diaryl-2-propen-1-ones) are alpha, beta-unsaturated ketones with cytotoxic and anticancer properties. Compound shows moderate interference with the DNA topoisomerase I	Homo sapiens
3-phenyl-1-(4'-hydroxyphenyl)-2-propen-1-one	chalcones (1,3-diaryl-2-propen-1-ones) are alpha, beta-unsaturated ketones with cytotoxic and anticancer properties. Compound shows moderate interference with the DNA topoisomerase I	Homo sapiens
additional information	3-(4-methoxyphenyl)-1-(4'-hydroxyphenyl)-2-propen-1-one and3-(2-thienyl)-1-(4'-hydroxyphenyl)-2-propen-1-one do not interfere with the enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
JURKAT cell	transformed human T (Jurkat) cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Homo sapiens

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Release 2023.1 (January 2023)