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Literature summary for 5.6.2.1 extracted from

  • Froehlich, R.F.; Juul, S.; Nielsen, M.B.; Vinther, M.; Veigaard, C.; Hede, M.S.; Andersen, F.F.
    Identification of a minimal functional linker in human topoisomerase I by domain swapping with Cre recombinase (2008), Biochemistry, 47, 7127-7136.
    View publication on PubMed
Search for more literature for 5.6.2.1

Cloned(Commentary)

Cloned (Comment) Organism
transformed into the yeast Saccharomyces cerevisiae top1alpha strain RS190 by the lithium acetate procedure Homo sapiens

Protein Variants

Protein Variants Comment Organism
Cropo4 chimeric enzyme, human topo I having residues 631-717 replaced by residues 314-317 of Cre Homo sapiens
Cropo6 chimeric enzyme, human topo I having residues 631-717 replaced by residues 312-317 of Cre Homo sapiens
Cropo8 chimeric enzyme, human topo I having residues 631-717 replaced by residues 312-319 of Cre Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
camptothecin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
negatively supercoiled DNA
-
 Homo sapiens relaxed DNA
-
 ?

Synonyms

Synonyms Comment Organism
human topo I
-
 Homo sapiens
Topo I
-
 Homo sapiens
Topoisomerase I type IB topoisomerase Homo sapiens