Literature summary for 5.6.2.1 extracted from

Rockstroh, A.; Kleinert, A.; Kramer, M.; Grosse, F.; Soe, K.
Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner (2007), Oncogene, 26, 123-131.

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Inhibitors

Inhibitors	Comment	Organism	Structure
colcemid	microtubule inhibitor, arrests cells in M phase, followed by induction of apotosis, 1 and 5 ng/ml colcemid display only modest cytotoxic effects. 10, 50 and 100 ng/ml induce pronounced cell death as measured by flow cytometry analysis	Homo sapiens
additional information	tumor suppressor p53 not only plays a key role in the regulation of the htopoI response to UV-C irradiation but also to treatment with colcemid	Homo sapiens
Tumor necrosis factor alpha	TNFalpha induces receptor-mediated apotosis. Receptor-mediated apoptosis induced by TNFalpha results in a very strong htopoI damage response, further indicating a general involvement of htopoI in apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
hTopoI	-	Homo sapiens
Topoisomerase I	-	Homo sapiens

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Release 2023.1 (January 2023)