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Literature summary for 5.6.2.1 extracted from
- Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site (2007), J. Mol. Biol., 365, 561-569.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | anticancer agents that target TOP1 achieve their cytotoxic effects by stabilizing and trapping the cleavable TOP1-DNA complex, which ultimately leads to the accumulation of DNA strand breaks and cell death | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-phenyl-2'-(indolo-6-yl)bibenzimidazole | 5P2'IBB | Homo sapiens |  |
| Hoechst 33258 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topoisomerase I | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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