Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.1 extracted from

  • van der Merwe, M.; Bjornsti, M.A.
    Mutation of GLY721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin (2007), J. Biol. Chem., 283, 3305-3315.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Protein Variants

Protein Variants Comment Organism
G721D Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721E Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721F Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721L Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721N Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721Q Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
G721V Single amino acid substitutions of yeast Gly721 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
L720E Single amino acid substitutions of Leu720 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae
L720Q Single amino acid substitutions of Leu720 alters Top1p sensitivity to camptothecin Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
camptothecin anti cancer drug (CPT) Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
DNA topoisomerase 1
-
 Saccharomyces cerevisiae
Top1p
-
 Saccharomyces cerevisiae