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Literature summary for 5.6.2.1 extracted from

  • Qin, Y.; Pang, J.Y.; Chen, W.H.; Zhao, Z.Z.; Liu, L.; Jiang, Z.H.
    Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids (2007), Chem. Biodivers., 4, 481-487.
    View publication on PubMed
Search for more literature for 5.6.2.1

Application

Application Comment Organism
drug development dimeric compounds are promising candidates to be further elaborated as anticancer leads Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
10-methoxy-9-{2-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]ethoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
10-methoxy-9-{3-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]propoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
10-methoxy-9-{4-[(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium-3-yl)oxy]butoxy}[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
3,3'-[butane-1,4-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
3,3'-[ethane-1,2-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active. Strongly stabilize the enzyme-DNA binary complex at low concentration (50–100microM). From 0.1 to 1 mM, their ability to stabilize is weak Homo sapiens
3,3'-[propane-1,3-diylbis(oxy)]bis(2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[butane-1,4-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[ethane-1,2-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium)dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[heptane-1,7-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[hexane-1,6-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[pentane-1,5-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active Homo sapiens
9,9'-[propane-1,3-diylbis(oxy)]bis(10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) dichloride synthetic protoberberine alkaloid, highly active. Strongly stabilize the enzyme-DNA binary complex at low concentration (50–100microM). From 0.1 to 1 mM, their ability to stabilize is weak Homo sapiens
9-O-(2-aminoethyl)berberine synthetic protoberberine alkaloid Homo sapiens
9-O-(2-hydroxyethyl)berberine synthetic protoberberine alkaloid Homo sapiens
9-O-[2-(1H-imidazol-1-yl)ethyl]berberine synthetic protoberberine alkaloid Homo sapiens
9-O-[2-(4-methylpiperazin-1-yl)ethyl]berberine synthetic protoberberine alkaloid Homo sapiens
Berberine natural protoberberine alkaloid Homo sapiens
berberrubine natural protoberberine alkaloid Homo sapiens
camptothecin topoisomerase I poison Homo sapiens
coptisine natural protoberberine alkaloid Homo sapiens
Jatrorrhizine natural protoberberine alkaloid Homo sapiens
jatrorubine natural protoberberine alkaloid Homo sapiens
additional information series of natural and synthetic protoberberine alkaloid evaluated for their inhibitory activities towards DNA topoisomerase I. Natural, monomeric protoberberine alkaloids and their mono-modified congeners show only minor activities. Most of the dimeric protoberberine alkaloids are highly active Homo sapiens
palmatine natural protoberberine alkaloid Homo sapiens
palmatrubine natural protoberberine alkaloid Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
 Homo sapiens
Topoisomerase I
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 Homo sapiens