Literature summary for 5.6.2.1 extracted from

Alpan, A.S.; Gunes, H.S.; Topcu, Z.
1H-Benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors (2007), Acta Biochim. Pol., 54, 561-565.

Search for more literature for 5.6.2.1

Application

Application	Comment	Organism
drug development	topoisomerase poisoning has been recognized as an effective approach for the development of chemotherapeutics	Mammalia

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(1H-benzimidazole-2-yl)phenol	Cpd III, 1H-benzimidazole derivative	Mammalia
5-chloro-4-(1H-benzimidazole-2-yl)phenol	Cpd I, 1H-benzimidazole derivative	Mammalia
5-methyl-4-(1H-benzimidazole-2-yl)phenol	Cpd II, 1H-benzimidazole derivative	Mammalia
camptothecin	inhibitor of topoisomerase I	Mammalia

Organism

Organism	UniProt	Comment	Textmining
Mammalia	-	-	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Mammalia
Topo I	-	Mammalia

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Release 2023.1 (January 2023)