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Literature summary for 5.6.2.1 extracted from

  • Mialon, A.; Sankinen, M.; Soderstrom, H.; Junttila, T.T.; Holmstrom, T.; Koivusalo, R.; Papageorgiou, A.C.; Johnson, R.S.; Hietanen, S.; Elenius, K.; Westermarck, J.
    DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation (2005), Mol. Cell. Biol., 25, 5040-5051.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Topo I is the first endogenous interaction partner for c-Jun in the regulation of cancer cell proliferation. Topo I and JNK-c Jun pathway cooperate in the regulation of eGFR gene expression and in the proliferation of HT-1080 cells ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Topo I is the first endogenous interaction partner for c-Jun in the regulation of cancer cell proliferation. Topo I and JNK-c Jun pathway cooperate in the regulation of eGFR gene expression and in the proliferation of HT-1080 cells Homo sapiens ?
-
?