Literature summary for 5.6.2.1 extracted from

Daroui, P.; Desai, S.D.; Li, T.K.; Liu, A.A.; Liu, L.F.
Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death (2004), J. Biol. Chem., 279, 14587-14594.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	H2O2 induces topoisomerase I-mediated DNA damage and cell death. H2O2 promotes the trapping of topoisomerase I on oxidative DNA lesions to form TOP1-DNA cleavage complexes that contribute to H2O2 toxicity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	H2O2 induces topoisomerase I-mediated DNA damage and cell death. H2O2 promotes the trapping of topoisomerase I on oxidative DNA lesions to form TOP1-DNA cleavage complexes that contribute to H2O2 toxicity	Saccharomyces cerevisiae	?	-	?

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Release 2023.1 (January 2023)