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Literature summary for 5.6.2.1 extracted from
- Functional characterization of Caenorhabditis elegans DNA topoisomerase IIIalpha (2000), Nucleic Acids Res., 28, 2012-2017.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full-length cDNA, expression in Escherichia coli | Caenorhabditis elegans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Caenorhabditis elegans | when enzyme expression is interfered with by a cognate double-stranded RNA injection, pleiotropic phenotypes with abnormalities in germ cell proliferation, oogenesis and embryogenesis appeare | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | O61660 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | when enzyme expression is interfered with by a cognate double-stranded RNA injection, pleiotropic phenotypes with abnormalities in germ cell proliferation, oogenesis and embryogenesis appeare | Caenorhabditis elegans | ? | - |
? | |
| negatively supercoiled DNA | - |
Caenorhabditis elegans | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase IIIalpha | - |
Caenorhabditis elegans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 52 | 57 | removal of negative DNA supercoils | Caenorhabditis elegans |
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