Literature summary for 5.6.2.1 extracted from

Feinberg, H.; Lima, C.D.; Mondragon, A.
Conformational changes in E. coli DNA topoisomerase I (1999), Nat. Struct. Biol., 6, 918-922.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging-drop vapor-diffusion method, fragment of the enzyme comprising residues 214-477	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P06612	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme changes conformation dramatically during the reaction cycle in order to accomplish these transformations. A 30000 Da fragment moves away from the rest of the protein to create an entrance into the central whole in the protein. This fragment can change conformation significantly. The fragment is composed of two domains, and while the domains themselves remain largely unchanged, their relative arrangement can change dramatically	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)