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Literature summary for 5.6.2.1 extracted from
- Characterization of recombinant human DNA topoisomerase IIIalpha activity expressed in yeast (2000), J. Biochem., 127, 1109-1113.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression mutant cells of Saccharomyces cerevisiae | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| negatively supercoiled DNA | the activity of the protein in supercoil removal is limited and biphasic: in the first phase it progressively changes the linking-number of hypernegatively supercoiled DNA, but only to the superhelicity of a regular negative supercoil, in the second phase the enzyme relaxes the DNA further, but only slightly and slowly. The C-terminal 334 amino acids are unnecessary for activity, suggesting that this region, and perhaps the entire protein is involved in a function other than supercoil removal | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase IIIalpha | - |
Homo sapiens |
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