Literature summary for 5.6.2.1 extracted from

Deady, L.W.; Kaye, A.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors (1997), J. Med. Chem., 40, 2040-2046.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-[2-(Dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines	-	Homo sapiens
N-[2-(Dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA	relaxation	Mus musculus	relaxed closed circular DNA	-	?
supercoiled DNA	relaxation	Homo sapiens	relaxed closed circular DNA	-	?

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Release 2023.1 (January 2023)