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Literature summary for 5.6.2.1 extracted from

  • Pommier, Y.; Pourquier, P.; Fan, Y.; Strumberg, D.
    Mechanism of the action of eucaryotic DNA topoisomerase I and drugs targeted to the enzyme (1998), Biochim. Biophys. Acta, 1400, 84-105.
No PubMed abstract available

Application

Application Comment Organism
pharmacology target of a novel class of anticancer drugs the camptothecins eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information eukaryota role of topoisomerase I in DNA replication, transcription and recombination ?
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?

Organism

Organism UniProt Comment Textmining
eukaryota
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role of topoisomerase I in DNA replication, transcription and recombination eukaryota ?
-
?
supercoiled DNA relaxation eukaryota relaxed closed circular DNA
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?