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Literature summary for 5.6.2.1 extracted from

  • Knudsen, B.R.; Straub, T.; Boege, F.
    Separation and functional analysis of eukaryotic DNA topoisomerases by chromatography and electrophoresis (1996), J. Chromatogr., 684, 307-321.
    View publication on PubMed
Search for more literature for 5.6.2.1

Application

Application Comment Organism
pharmacology important cellular target in the treatment of human cancer eukaryota

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in yeast Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 eukaryota 5634
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens
-
 ?
-
 ?
additional information eukaryota controls the DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through the transient gaps, plays a crucial role in the regulation of the physiological function of the genome ?
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme overexpressed in yeast Homo sapiens
strategy for purifying eukaryotic type I topoisomerases eukaryota

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Homo sapiens ?
-
 ?
additional information controls the DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through the transient gaps, plays a crucial role in the regulation of the physiological function of the genome eukaryota ?
-
 ?
supercoiled DNA relaxation eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation Homo sapiens relaxed closed circular DNA
-
 ?