Application | Comment | Organism |
---|---|---|
pharmacology | important cellular target in the treatment of human cancer | eukaryota |
Cloned (Comment) | Organism |
---|---|
overexpressed in yeast | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
eukaryota | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | - |
? | - |
? | |
additional information | eukaryota | controls the DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through the transient gaps, plays a crucial role in the regulation of the physiological function of the genome | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
eukaryota | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme overexpressed in yeast | Homo sapiens |
strategy for purifying eukaryotic type I topoisomerases | eukaryota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Homo sapiens | ? | - |
? | |
additional information | controls the DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through the transient gaps, plays a crucial role in the regulation of the physiological function of the genome | eukaryota | ? | - |
? | |
supercoiled DNA | relaxation | eukaryota | relaxed closed circular DNA | - |
? | |
supercoiled DNA | relaxation | Homo sapiens | relaxed closed circular DNA | - |
? |