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Literature summary for 5.6.2.1 extracted from

  • Gellert, M.
    DNA topoisomerases (1981), Annu. Rev. Biochem., 50, 879-910.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Gallus gallus 5634
-
nucleus
-
Drosophila sp. (in: flies) 5634
-
nucleus associated with chromatin Mus musculus 5634
-
nucleus associated with chromatin Homo sapiens 5634
-
nucleus associated with chromatin Rattus norvegicus 5634
-
nucleus associated with chromatin Bos taurus 5634
-
nucleus associated with chromatin Xenopus laevis 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Gallus gallus
Mg2+
-
Vaccinia virus
Mg2+ required Escherichia coli
Mg2+ active in absence of Mg2+ Mus musculus
Mg2+ active in absence of Mg2+ Homo sapiens
Mg2+ active in absence of Mg2+ Rattus norvegicus
Mg2+ active in absence of Mg2+ Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
1 * 110000, denaturing PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus enzyme controls the topological state of DNA ?
-
?
additional information Drosophila sp. (in: flies) enzyme controls the topological state of DNA ?
-
?
additional information Mus musculus enzyme controls the topological state of DNA ?
-
?
additional information Escherichia coli enzyme controls the topological state of DNA ?
-
?
additional information Homo sapiens enzyme controls the topological state of DNA ?
-
?
additional information Rattus norvegicus enzyme controls the topological state of DNA ?
-
?
additional information Bos taurus enzyme controls the topological state of DNA ?
-
?
additional information Priestia megaterium enzyme controls the topological state of DNA ?
-
?
additional information Xenopus laevis enzyme controls the topological state of DNA ?
-
?
additional information Micrococcus luteus enzyme controls the topological state of DNA ?
-
?
additional information Anas platyrhynchos enzyme controls the topological state of DNA ?
-
?
additional information Platyrrhini enzyme controls the topological state of DNA ?
-
?
additional information Vaccinia virus enzyme controls the topological state of DNA ?
-
?
additional information Echinoidea enzyme controls the topological state of DNA ?
-
?
additional information salmon enzyme controls the topological state of DNA ?
-
?

Organism

Organism UniProt Comment Textmining
Anas platyrhynchos
-
-
-
Bos taurus
-
calf
-
Drosophila sp. (in: flies)
-
-
-
Echinoidea
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Micrococcus luteus
-
-
-
Mus musculus
-
-
-
Platyrrhini
-
-
-
Priestia megaterium
-
-
-
Rattus norvegicus
-
a nuclear and a mitochondrial form
-
salmon
-
-
-
Vaccinia virus
-
-
-
Xenopus laevis
-
in Ref. 21 steht nur Xenopus sp.
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
Drosophila sp. (in: flies)
-
egg
-
Echinoidea
-
embryo
-
Drosophila sp. (in: flies)
-
embryo
-
Mus musculus
-
erythrocyte
-
Gallus gallus
-
erythrocyte
-
Anas platyrhynchos
-
HeLa cell
-
Homo sapiens
-
testis
-
salmon
-
thymus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme controls the topological state of DNA Gallus gallus ?
-
?
additional information enzyme controls the topological state of DNA Drosophila sp. (in: flies) ?
-
?
additional information enzyme controls the topological state of DNA Mus musculus ?
-
?
additional information enzyme controls the topological state of DNA Escherichia coli ?
-
?
additional information enzyme controls the topological state of DNA Homo sapiens ?
-
?
additional information enzyme controls the topological state of DNA Rattus norvegicus ?
-
?
additional information enzyme controls the topological state of DNA Bos taurus ?
-
?
additional information enzyme controls the topological state of DNA Priestia megaterium ?
-
?
additional information enzyme controls the topological state of DNA Xenopus laevis ?
-
?
additional information enzyme controls the topological state of DNA Micrococcus luteus ?
-
?
additional information enzyme controls the topological state of DNA Anas platyrhynchos ?
-
?
additional information enzyme controls the topological state of DNA Platyrrhini ?
-
?
additional information enzyme controls the topological state of DNA Vaccinia virus ?
-
?
additional information enzyme controls the topological state of DNA Echinoidea ?
-
?
additional information enzyme controls the topological state of DNA salmon ?
-
?
supercoiled DNA relaxation Gallus gallus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Drosophila sp. (in: flies) relaxed closed circular DNA
-
?
supercoiled DNA relaxation Mus musculus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Escherichia coli relaxed closed circular DNA
-
?
supercoiled DNA relaxation Homo sapiens relaxed closed circular DNA
-
?
supercoiled DNA relaxation Rattus norvegicus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Bos taurus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Priestia megaterium relaxed closed circular DNA
-
?
supercoiled DNA relaxation Xenopus laevis relaxed closed circular DNA
-
?
supercoiled DNA relaxation Micrococcus luteus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Anas platyrhynchos relaxed closed circular DNA
-
?
supercoiled DNA relaxation Platyrrhini relaxed closed circular DNA
-
?
supercoiled DNA relaxation Vaccinia virus relaxed closed circular DNA
-
?
supercoiled DNA relaxation Echinoidea relaxed closed circular DNA
-
?
supercoiled DNA relaxation salmon relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Drosophila sp. (in: flies) relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Mus musculus relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Homo sapiens relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Rattus norvegicus relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Bos taurus relaxed closed circular DNA
-
?
supercoiled DNA positive and negative supercoiled DNA Vaccinia virus relaxed closed circular DNA
-
?
supercoiled DNA specific for negatively supercoiled DNA, no activity with positively supercoiled DNA Escherichia coli relaxed closed circular DNA
-
?

Subunits

Subunits Comment Organism
monomer
-
Gallus gallus
monomer
-
Mus musculus
monomer
-
Homo sapiens
monomer
-
Vaccinia virus
monomer 1 * 110000, denaturing PAGE Escherichia coli