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Literature summary for 5.6.2.1 extracted from

  • Ivanov, V.A.; Melnikov, A.A.; Terpilovska, O.N.
    DNA topoisomerase I from rat brain neurons (1986), Biochim. Biophys. Acta, 866, 154-160.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
poly(dG) not by other homopolymerical deoxyribonucleotides Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ stimulates, optimal concentration: 175-200 mM. K+ stimulates 10-15% more effectively than Na+ Rattus norvegicus
Na+ stimulates, optimal concentration: 175-200 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex neuron Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA relaxation Rattus norvegicus relaxed closed circular DNA
-
?
supercoiled DNA enzyme links to the 3' ends of the broken DNA strands Rattus norvegicus relaxed closed circular DNA
-
?

Subunits

Subunits Comment Organism
? proteins with MW 75000, 83000, 91000 or 100000 with DNA topoisomerase I activity are detected Rattus norvegicus