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Literature summary for 5.6.2.1 extracted from
- Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells (1983), J. Biol. Chem., 258, 12728-12732.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | - |
Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 98000 | - |
1 * 98000, enzyme form p98, SDS-PAGE. The two enzyme form P98 and p102 are structurally related | Mus musculus |
| 102000 | - |
1 * 102000, enzyme form p102, SDS-PAGE. The two enzyme forms P98 and p102 are structurally related | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| FM3A cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Mus musculus | relaxed closed circular DNA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 98000, enzyme form p98, SDS-PAGE. The two enzyme form P98 and p102 are structurally related | Mus musculus |
| monomer | 1 * 102000, enzyme form p102, SDS-PAGE. The two enzyme forms P98 and p102 are structurally related | Mus musculus |
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