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Literature summary for 5.6.1.9 extracted from

  • Hans, M.; Buckel, W.; Bill, E.
    Spectroscopic evidence for an all-ferrous [4Fe-4S]0 cluster in the superreduced activator of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans (2008), J. Biol. Inorg. Chem., 13, 563-574 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.9

Organism

Organism UniProt Comment Textmining
Acidaminococcus fermentans P11568
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Acidaminococcus fermentans DSM 20731 P11568
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O
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 Acidaminococcus fermentans 2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase
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 ?
2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O
-
 Acidaminococcus fermentans DSM 20731 2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase
-
 ?

Cofactor

Cofactor Comment Organism Structure
4Fe-4S-center the reduced [4Fe-4S]+ cluster containing activator transfers one electron to the dehydratase. Only one-electron transfer steps are involved in dehydratase catalysis Acidaminococcus fermentans