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Literature summary for 5.6.1.7 extracted from

  • Amit, M.; Weisberg, S.J.; Nadler-Holly, M.; McCormack, E.A.; Feldmesser, E.; Kaganovich, D.; Willison, K.R.; Horovitz, A.
    Equivalent mutations in the eight subunits of the chaperonin CCT produce dramatically different cellular and gene expression phenotypes (2010), J. Mol. Biol., 401, 532-543.
    View publication on PubMed
Search for more literature for 5.6.1.7

Protein Variants

Protein Variants Comment Organism
additional information identical mutations in the different CCT subunits lead to different phenotypes. Mutation in subunit CCT2 displays heat sensitivity and cold sensitivity for growth, have an excess of actin patches, and are the only strain here generated that is pseudo-diploid. Cells with the mutation in subunit CCT7 are the only ones to accumulate juxtanuclear protein aggregates that may reflect an impaired stress response in this strain Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Saccharomyces cerevisiae 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a folded polypeptide Saccharomyces cerevisiae the enzyme assists the folding of actins, tubulins, and other proteins in an ATP-dependent manner ADP + phosphate + an unfolded polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a folded polypeptide
-
 Saccharomyces cerevisiae ADP + phosphate + an unfolded polypeptide
-
 ?
ATP + H2O + a folded polypeptide the enzyme assists the folding of actins, tubulins, and other proteins in an ATP-dependent manner Saccharomyces cerevisiae ADP + phosphate + an unfolded polypeptide
-
 ?

Subunits

Subunits Comment Organism
hexadecamer chaperonin CCT is a complex formed by two back-to-back stacked hetero-octameric rings Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
chaperonin CCT
-
 Saccharomyces cerevisiae
chaperonin-containing TCP-1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme assists the folding of actins, tubulins, and other proteins in an ATP-dependent manner Saccharomyces cerevisiae