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Literature summary for 5.6.1.6 extracted from
- Conformational changes of CFTR upon phosphorylation and ATP binding (2017), Cell, 170, 483-491.e8 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293S cells | Danio rerio |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E1372Q | the mutation abolishes ATP hydrolysis and slows the pore-closing rate by about 1000fold as compared to the wild type enzyme | Danio rerio |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | Danio rerio | - |
ADP + phosphate + open Cl- channel | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | Q1LX78 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of the enzyme leads to structural transitions that promote channel widening while ahead of extracellular gate opening | Danio rerio |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| GFP nanobody-coupled resin column chromatography | Danio rerio |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | - |
Danio rerio | ADP + phosphate + open Cl- channel | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Danio rerio |
| cystic fibrosis transmembrane conductance regulator | - |
Danio rerio |
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