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Literature summary for 5.6.1.6 extracted from
- Specific stabilization of CFTR by phosphatidylserine (2017), Biochim. Biophys. Acta, 1859, 289-293 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylserine | the enzyme requires phosphatidylserine for maximum ATPase activity | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in D-727 cells | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| phosphatidylserine specifically stabilizes ATPase activity of the purified enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1.5 mM used in assay conditions | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 212000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | Homo sapiens | - |
ADP + phosphate + open Cl- channel | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCC7 | - |
Homo sapiens |
| CFTR | - |
Homo sapiens |
| cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | 25 | the enzyme, in the absence of lipid or nucleotide, is unstable at room temperature, losing approximately half its ATP hydrolysis activity over a 30 minute period. The melting temperature is 22.7°C | Homo sapiens |
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Release 2023.1 (January 2023)
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