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Literature summary for 5.6.1.6 extracted from
- Cryo-EM Visualization of an active high open probability CFTR anion channel (2018), Biochemistry, 57, 6234-6246 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in baby hamster kidney cells | Gallus gallus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| inactive and active states of a thermally stabilized enzyme, cryo-electron microscopy | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | Gallus gallus | - |
ADP + phosphate + open Cl- channel | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | A0M8U4 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Gallus gallus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Co-Talon resin column chromatography | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | - |
Gallus gallus | ADP + phosphate + open Cl- channel | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCC7 | - |
Gallus gallus |
| CFTR | - |
Gallus gallus |
| cystic fibrosis transmembrane conductance regulator | - |
Gallus gallus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is crucial to epithelial salt and water homeostasis | Gallus gallus |
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