Literature summary for 5.6.1.6 extracted from

Hwang, T.C.; Sheppard, D.N.
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation (2009), J. Physiol., 587, 2151-2161.

Search for more literature for 5.6.1.6

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation of the unique regulatory domain by the cAMP-dependent protein kinase is a prerequisite for channel opening. CFTR phosphorylation by different kinases might 1. activate, e.g. cGMP-dependent protein kinase II, 2. inhibit, e.g.AMP-activated protein kinase, or 3. have dual effects on channel activity depending on the CFTR construct studied and the consensus phosphorylation site phosphorylated	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + closed Cl- channel	binding mode of ATP in the CFTR nucleotide-binding domain NBD1-NBD2 dimer, organisation of the ATP-binding sites in CFTR involving Walker A and B motifs, and the signature sequence LSGGQ, and conformational changes of the CFTR Cl- channel during channel gating, overview	Homo sapiens	ADP + phosphate + open Cl- channel	-	?
additional information	mechanism of action of small molecules that modulate CFTR channel gating	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	structure modelling, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CFTR	-	Homo sapiens

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Release 2023.1 (January 2023)