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Literature summary for 5.6.1.6 extracted from

  • Fatehi, M.; Linsdell, P.
    State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore (2008), J. Biol. Chem., 283, 6102-6109.
    View publication on PubMed
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
cAMP stimulates the ion channel function Homo sapiens
diphosphate activates the enzyme ion channel Homo sapiens
KCN without cAMP stimulation, KCN treatment increases CFTR Cl- conductance by 1.95fold, whereas after cAMP stimulation KCN treatment increases conductance by 13.7fold Homo sapiens

Protein Variants

Protein Variants Comment Organism
F337C the cysteine introduced at a position in the pore-lining TM6 region of CFTR is accessible to extracellular methanesulfonate reagents, the mutant becomes significantly more inwardly rectified in the presence of sodium (2-sulfonatoethyl)methanesulfonate Homo sapiens
K335C the cysteine introduced at a position in the pore-lining TM6 region of CFTR is accessible to extracellular methanesulfonate reagents Homo sapiens
R334C the cysteine introduced at a position in the pore-lining TM6 region of CFTR is accessible to extracellular methanesulfonate reagents Homo sapiens
S341C the cysteine introduced at a position in the pore-lining TM6 region of CFTR is accessible to extracellular methanesulfonate reagents, charge-dependent changes in I-V shape in this mutant, indicating that deposition of charge at this position also alters anion movement in the pore Homo sapiens
T338C Au(CN)2 - can modify T338C-CFTR with or without cAMP stimulation in contrast to the wild-type enzyme Homo sapiens
T338C the cysteine introduced at a position in the pore-lining TM6 region of CFTR is accessible to extracellular methanesulfonate reagents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Au(CN)2- inhibits the ion channel function Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme acts as an ion channel, e.g. transporting chloride and the anionic cysteine-reactive reagents methanesulfonate sodium (2-sulfonatoethyl)methanesulfonate, organic mercurial 4-chloromercuriphenylsulfonic acid, and the permeant anion Au(CN)2-, but only in activated status, in nonactivated channels some ion selectivity mechanism exists to exclude anions yet permit cations into the channel pore from the extracellular solution. Activation of CFTR channels involves a conformational change in the pore that removes a strong selectivity against anion entry from the extracellular solution ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme acts as an ion channel, e.g. transporting chloride and the anionic cysteine-reactive reagents methanesulfonate sodium (2-sulfonatoethyl)methanesulfonate, organic mercurial 4-chloromercuriphenylsulfonic acid, and the permeant anion Au(CN)2-, but only in activated status, in nonactivated channels some ion selectivity mechanism exists to exclude anions yet permit cations into the channel pore from the extracellular solution. Activation of CFTR channels involves a conformational change in the pore that removes a strong selectivity against anion entry from the extracellular solution Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens