Cloned (Comment) | Organism |
---|---|
expression in BHK 21 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E1371S | mutation in CFTR mutant lacking all cysteine residues due to replacement by alanine, except Cys590 and Cys592, which are replaced by leucine. Mutant can be locked in an open state | Homo sapiens |
F508C/E1371S | mutation in CFTR mutant lacking all cysteine residues due to replacement by alanine, except Cys590 and Cys592, which are replaced by leucine. Mutation F508C prevents the cysless E1371S channel from maintaining the permanently open state, allowing closing to occur. Specifically, benzyl-methanethiosulphonate modification restores the gating behaviour to that of cysless E1371S | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |