Literature summary for 5.6.1.6 extracted from

Ferrera, L.; Pincin, C.; Moran, O.
Characterization of a 7,8-benzoflavone double effect on CFTR Cl(-) channel activity (2007), J. Membr. Biol., 220, 1-9.

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Activating Compound

Activating Compound	Comment	Organism	Structure
2-(pyridin-4-yl)-4H-benzo[h]chromen-4-one	i.e. UCCF-029. Concentrations below 50 nM increase the open probability of the channel, favouring the channel transition to the an activated state. Levels above 50 nM determine inhibition of the channel by a reduction of the open time. UCCF-029 does not interfere with binding of ATP	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(pyridin-4-yl)-4H-benzo[h]chromen-4-one	i.e. UCCF-029. Concentrations below 50 nM increase the open probability of the channel, favouring the channel transition to the an activated state. Levels above 50 nM determine inhibition of the channel by a reduction of the open time. UCCF-029 does not interfere with binding of ATP	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform CFTR	-

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Release 2023.1 (January 2023)