Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.1.6 extracted from

  • Zhou, Z.; Wang, X.; Liu, H.Y.; Zou, X.; Li, M.; Hwang, T.C.
    The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics (2006), J. Gen. Physiol., 128, 413-422.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
W401G little effect on the sensitivity of the channel opening rate to the concentration of ATP, but shortens the open time constant Homo sapiens
Y1219G decrease in the apparent affinity for ATP by 50fold Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P13569 isoform CFTR
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel asymmetric motion of the nucleotide binding domains 1 and 2 during channel gating. Opening of the channel is initiated by ATP at the nucleotide-binding domain 2 site, whereas separation of the nucleotide-binding domain dimer at the nucleotide-binding domain 1 site constitutes the rate-limiting step in channel closing Homo sapiens