Cloned (Comment) | Organism |
---|---|
expression in CHO cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
W401G | little effect on the sensitivity of the channel opening rate to the concentration of ATP, but shortens the open time constant | Homo sapiens |
Y1219G | decrease in the apparent affinity for ATP by 50fold | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13569 | isoform CFTR | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel | asymmetric motion of the nucleotide binding domains 1 and 2 during channel gating. Opening of the channel is initiated by ATP at the nucleotide-binding domain 2 site, whereas separation of the nucleotide-binding domain dimer at the nucleotide-binding domain 1 site constitutes the rate-limiting step in channel closing | Homo sapiens |