Literature summary for 5.6.1.6 extracted from

Ajonuma, L.C.; Tsang, L.L.; Zhang, G.H.; Wong, C.H.; Lau, M.C.; Ho, L.S.; Rowlands, D.K.; Zhou, C.X.; Ng, C.P.; Chen, J.; Xu, P.H.; Zhu, J.X.; Chung, Y.W.; Chan, H.C.
Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome (2005), Mol. Endocrinol., 19, 3038-3044.

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Activating Compound

Activating Compound	Comment	Organism	Structure
estrogen	high amounts upregulate CFTR expression	Rattus norvegicus

Application

Application	Comment	Organism
medicine	CFTR is involved in the pathogenesis of ovarian hyperstimulation syndrome by reproduction treatments, upon ovarian hyperstimulation enhanced CFTR expression and channel activity	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	CFTR mutants tm1Unc, no detectable ovarian hyperstimulation syndrome symptoms by ovarian hyperstimulation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Antibody	inhibits CFTR, alleviation of ovarian hyperstimulation syndrome symptoms	Rattus norvegicus
progesterone	supresses CFTR expression, alleviation of ovarian hyperstimulation syndrome symptoms	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary	-	Rattus norvegicus	-
uterus	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
CFTR	-	Rattus norvegicus
cystic fibrosis transmembrane conductance regulator	-	Rattus norvegicus

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Release 2023.1 (January 2023)