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Literature summary for 5.6.1.6 extracted from
- Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells (2005), J. Physiol., 568, 483-495.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxytryptamine | activates CFTR in myocytes | Mus musculus |  |
| A23187 | - |
Mus musculus | |
| cAMP | stimulates | Mus musculus | |
| forskolin | stimulates, potentiation in the presence of genistein | Mus musculus | |
| genistein | stimulates, potentiation in the presence of forskolin | Mus musculus | |
| IBMX | - |
Mus musculus | |
| isoproterenol | stimulates | Mus musculus | |
| MPB-07 | stimulates | Mus musculus | |
| MPB-91 | stimulates | Mus musculus | |
| Vasoactive intestinal peptide | stimulates | Mus musculus | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | novel mechanism for regulation of the vascular tone by cAMP-dependent CFTR chloride channels in vascular smooth muscle cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | CFTR knockout mice B6, aortas significantly more constricted than control arteries, less sensitive to the relaxing action of VIP, and fail to relax in the presence of CFTR activators | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CFTRinh-172 | - |
Mus musculus | |
| diphenylamine-2,2'-dicarboxylic acid | fully inhibits | Mus musculus | |
| glibenclamide | fully inhibits | Mus musculus | |
| additional information | not inhibited by calixarene | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulates | Mus musculus | |
| K+ | activates CFTR in myocytes | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Mus musculus | - |
| myocyte | - |
Mus musculus | - |
| vascular smooth muscle cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Mus musculus |
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Release 2023.1 (January 2023)
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