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Literature summary for 5.6.1.6 extracted from

  • Csanady, L.; Chan, K.W.; Nairn, A.C.; Gadsby, D.C.
    Functional roles of nonconserved structural segments in CFTRs NH2-terminal nucleotide binding domain (2005), J. Gen. Physiol., 125, 43-55.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Application

Application Comment Organism
additional information unaltered phosphorylation and ATP dependence of macrosopic current in severed CFTR channels lacking nucleotide-binding domain 1 insertion or extension Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of CFTR residues 1-414 with residues 433-1480, or residues 1-633 with 668-1480 in Xenopus laevis oocytes, to yield split CFTR channels, that lack most of the insertion or extension, respectively Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information deletion of the insertion, but not the extension, of nucleotide-binding domain 1 speeds closing from locked-open bursts, omission of the nucleotide-binding domain 1 insertion or extension causes no major perturbation of the pore architecture Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Synonyms

Synonyms Comment Organism
CFTR
-
 Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens