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Literature summary for 5.6.1.6 extracted from
- Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel (2006), Exp. Physiol., 91, 123-129.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | functions as a Cl- channel, important in transepithelial salt and water transport, Cl-channel pore at the first and sixth transmembrane region, positive charges attract Cl- ions into the pore | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | anion binding makes the Cl-channel pore susceptible to inhibitors | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | anions bind inside the Cl-channel pore, the pore discriminates between anions | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Homo sapiens |
| cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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