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Literature summary for 5.6.1.6 extracted from
- Identification of CFTR activators and inhibitors: chance or design? (2004), Curr. Opin. Pharmacol., 4, 497-503.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| benzimidazolone compounds | - |
Homo sapiens | |
| benzoquinolizinium compounds | - |
Homo sapiens | |
| flavonoid | - |
Homo sapiens | |
| fluorescein derivative | - |
Homo sapiens | |
| xanthine | - |
Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | CFTR is a phamacological target for activators and inhibitors, acivators are useful for phamacotherapy of cystic fibrosis, conversely, inhibitors are useful to treat secretory diarrhoea caused by enterotoxins | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-nitro-2(3-phenylpropylamino)benzoate | - |
Homo sapiens | |
| CFTRinh-172 | possibly inhibits CFTR currents by alteration of gating mechanisms | Homo sapiens | |
| diphenylamine-2-carboxylate | - |
Homo sapiens | |
| glibenclamide | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | airway | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Homo sapiens |
| cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
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