Cloned (Comment) | Organism |
---|---|
expression in Xenopus oocytes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Homo sapiens | ATPase that functions as a Cl- channel in which bursts of opening separate relatively long inburst closed times. ATP must bind at both catalytic sites before a CFTR channel can open. The opening is rate limiting by a slow step after binding that is rate limited by a slow step after binding that is sensitive to the structure of the polyphosphate chaIN: No further nucleotide binding to the open channel. Hydrolysis at nucleotide binding domain 2 preceds normal rapid channel closing. The integrity of the nucleotide binding domain 1 Walker A motif, and nucleotide bound there, influences the rate of exit from locked-open burst states | ADP + phosphate + open Cl- channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | ATPase that functions as a Cl- channel in which bursts of opening separate relatively long inburst closed times. ATP must bind at both catalytic sites before a CFTR channel can open. The opening is rate limiting by a slow step after binding that is rate limited by a slow step after binding that is sensitive to the structure of the polyphosphate chaIN: No further nucleotide binding to the open channel. Hydrolysis at nucleotide binding domain 2 preceds normal rapid channel closing. The integrity of the nucleotide binding domain 1 Walker A motif, and nucleotide bound there, influences the rate of exit from locked-open burst states | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CFTR Cl- channel | - |
Homo sapiens |