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Literature summary for 5.6.1.6 extracted from

  • Vergani, P.; Nairn, A.C.; Gadsby, D.C.
    On the mechanism of MgATP-dependent gating of CFTR Cl- channels (2003), J. Gen. Physiol., 121, 17-36.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Xenopus oocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens ATPase that functions as a Cl- channel in which bursts of opening separate relatively long inburst closed times. ATP must bind at both catalytic sites before a CFTR channel can open. The opening is rate limiting by a slow step after binding that is rate limited by a slow step after binding that is sensitive to the structure of the polyphosphate chaIN: No further nucleotide binding to the open channel. Hydrolysis at nucleotide binding domain 2 preceds normal rapid channel closing. The integrity of the nucleotide binding domain 1 Walker A motif, and nucleotide bound there, influences the rate of exit from locked-open burst states ADP + phosphate + open Cl- channel
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
Homo sapiens ADP + phosphate + open Cl- channel
-
?
ATP + H2O + closed Cl- channel ATPase that functions as a Cl- channel in which bursts of opening separate relatively long inburst closed times. ATP must bind at both catalytic sites before a CFTR channel can open. The opening is rate limiting by a slow step after binding that is rate limited by a slow step after binding that is sensitive to the structure of the polyphosphate chaIN: No further nucleotide binding to the open channel. Hydrolysis at nucleotide binding domain 2 preceds normal rapid channel closing. The integrity of the nucleotide binding domain 1 Walker A motif, and nucleotide bound there, influences the rate of exit from locked-open burst states Homo sapiens ADP + phosphate + open Cl- channel
-
?

Synonyms

Synonyms Comment Organism
CFTR Cl- channel
-
Homo sapiens