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Literature summary for 5.6.1.6 extracted from

  • Kogan, I.; Ramjeesingh, M.; Huan, L.J.; Wang, Y.; Bear, C.E.
    Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its ATPase activity (2001), J. Biol. Chem., 276, 11575-11581.
    View publication on PubMed
Search for more literature for 5.6.1.6

Protein Variants

Protein Variants Comment Organism
R347D inhibition by 10 mM glutathione is higher than that of the wild-type enzyme. The Km-value for ATP in presence of protein kinase A is 3fold lower than that of the wild-type enzyme. The Km-value for ATP in absence of protein kinase A is 1.1fold higher than that of the wild-type enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diphenylamine-2-carboxylate
-
 Homo sapiens
GSH 10 mM, 39% inhibition of wild-type enzyme, 63% inhibition of mutant enzyme R347D Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 ATP pH 7.5, 33°C, mutant enzyme R347D, in presence of protein kinase A Homo sapiens
1.1
-
 ATP pH 7.5, 33°C, mutant enzyme R347D, in absence of protein kinase A Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Synonyms

Synonyms Comment Organism
CFTR
-
 Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens