Literature summary for 5.6.1.6 extracted from

Lewis, H.A.; Buchanan, S.G.; Burley, S.K.; Conners, K.; Dickey, M.; Dorwart, M.; Fowler, R.; Gao, X.; Guggino, W.B.; Hendrickson, W.A.; Hunt, J.F.; Kearins, M.C.; Lorimer, D.; Maloney, P.C.; Post, K.W.; Rajashankar, K.R.; Rutter, M.E.; Sauder, J.M.; Shriver, S.; Thibodeau, P.H.; Thomas, P.J.; Zhang, M.; Zhao, X.; Emtage, S.
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator (2004), EMBO J., 23, 282-293.

Cloned(Commentary)

Cloned (Comment)	Organism
expression of wild-type nucleotide-binding domain 1 und a mutated version, K464A, in Escherichia coli	Mus musculus

Crystallization (Comment)	Organism
native and selenomethionyl nucleotide-binding domain 1, hanging-drop vapor-diffusion method	Mus musculus

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + closed Cl- channel	Mus musculus	the enzyme is an ATP-binding cassette transporter that functions as a chloride channel. Channel gating occurs through ATP binding in an nucleotide-binding domain 1-nucleotide-binding domain 2 nucleotide sandwich that forms upon displacement of nucleotide-binding domain 1 regulatory segments	ADP + phosphate + open Cl- channel	-	?

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Purification (Comment)	Organism
-	Mus musculus

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + closed Cl- channel	the enzyme is an ATP-binding cassette transporter that functions as a chloride channel. Channel gating occurs through ATP binding in an nucleotide-binding domain 1-nucleotide-binding domain 2 nucleotide sandwich that forms upon displacement of nucleotide-binding domain 1 regulatory segments	Mus musculus	ADP + phosphate + open Cl- channel	-	?

Synonyms	Comment	Organism
CFTR	-	Mus musculus
cystic fibrosis transmembrane conductance regulator	-	Mus musculus