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Literature summary for 5.6.1.6 extracted from

  • Kleizen, B.; Braakman, I.; de Jonge, H.R.
    Regulated trafficking of the CFTR chloride channel (2000), Eur. J. Cell Biol., 79, 544-556.
    View publication on PubMed
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
cAMP activates Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane endocytosis and recycling of CFTR at the apical membrane Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens CFTR is a conductance regulator as well as a Cl- channel, CFTR regulates other ion channel proteins ADP + phosphate + open Cl- channel
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 ?
ATP + H2O + closed Cl- channel Homo sapiens malfunction of CFTR causes cystic fibrosis ADP + phosphate + open Cl- channel
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the enzyme is synthesized in the ER and co-translationally undergoes core glycosylation as an initial step in CFTR processing. During CFTR traffic through the Golgi complex its two N-linked oligosaccharide chains are converted from high mannose to complex structures prior to its trafficking to the plasma membrane Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium apical membrane of epithelia Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel CFTR is a conductance regulator as well as a Cl- channel, CFTR regulates other ion channel proteins Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel malfunction of CFTR causes cystic fibrosis Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Subunits

Subunits Comment Organism
More enzyme of the ABC transporter family Homo sapiens