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Literature summary for 5.6.1.6 extracted from

  • Van Kuijck, M.A.; van Aubel, R.A.M.H.; Busch, A.E.; Lang, F.; Russell, F.G.M.; Bindels, R.J.M.; van Os, C.H.; Deen, P.M.T.
    Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP binding cassette transporter (1996), Proc. Natl. Acad. Sci. USA, 93, 5401-5406.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
cAMP activates Homo sapiens
cAMP activates Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Xenopus oocytes Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
5-nitro-2-(3-phenylpropylamine)benzoic acid
-
 Oryctolagus cuniculus
niflumic acid
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel Oryctolagus cuniculus EBCR is involved in hormone-regulated chloride reabsorption ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
epithelium
-
 Oryctolagus cuniculus
-
kidney basolateral localization mainly in the thick ascending limb of Henleย‘s loop, distal convoluted tubules and to a lesser extent connecting tubules Oryctolagus cuniculus
-
liver
-
 Oryctolagus cuniculus
-
small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel chloride channel Oryctolagus cuniculus ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel EBCR is involved in hormone-regulated chloride reabsorption Oryctolagus cuniculus ADP + phosphate + open Cl- channel
-
 ?

Synonyms

Synonyms Comment Organism
EBCR
-
 Oryctolagus cuniculus
epithelial basolateral chloride conductance regulator
-
 Oryctolagus cuniculus