Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.1.6 extracted from

  • Price, M.P.; Ishihara, H.; Sheppard, D.N.; Welsh, M.J.
    Function of Xenopus cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels and use of human-Xenopus chimeras to investigate the pore properties of CFTR (1996), J. Biol. Chem., 271, 25184-25191.
    View publication on PubMed
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
cAMP activates Homo sapiens
cAMP activates Xenopus sp.

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cells Xenopus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Xenopus sp. 16020
-
membrane apical membrane of epithelia Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
epithelium
-
 Xenopus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel anion permeability sequence: Br- = I-, Cl- Xenopus sp. ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel chloride channel Xenopus sp. ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel sequence differences in the first membrane-spanning domains in human and Xenopus sp. are responsible for the differences in the permeation properties of human and Xenopus CFTR, the first extracellular loop influences channel gating Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel sequence differences in the first membrane-spanning domains in human and Xenopus sp. are responsible for the differences in the permeation properties of human and Xenopus CFTR, the first extracellular loop influences channel gating Xenopus sp. ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel anion permeability sequence: Br- = Cl-, I- Xenopus sp. ADP + phosphate + open Cl- channel
-
 ?

Subunits

Subunits Comment Organism
More sequence differences in the first membrane-spanning domains in human and Xenopus sp. are responsible for the differences in the permeation properties of human and Xenopus CFTR, the first extracellular loop influences channel gating Homo sapiens
More sequence differences in the first membrane-spanning domains in human and Xenopus sp. are responsible for the differences in the permeation properties of human and Xenopus CFTR, the first extracellular loop influences channel gating Xenopus sp.