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Literature summary for 5.6.1.6 extracted from

  • Chen, M.; Zhang, J.T.
    Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes (1996), Mol. Membr. Biol., 13, 33-40.
    View publication on PubMed
Search for more literature for 5.6.1.6

Cloned(Commentary)

Cloned (Comment) Organism
full-length and truncated -fusion CFTR cDNAs are cloned into pGEM-4z vector and direct translation in a rabbit reticulocyte lysate system Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane microsomal membrane Homo sapiens 16020
-
membrane CFTR contains an uncleavable signal sequence and its membrane targeting and insertion may depend on the signal recognition particle and the signal recognition particle receptor Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens enzyme is regulated by cAMP ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel Homo sapiens malfunction of CFTR causes cystic fibrosis ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel enzyme is regulated by cAMP Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel malfunction of CFTR causes cystic fibrosis Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Subunits

Subunits Comment Organism
More enzyme of the ABC transporter family Homo sapiens