Protein Variants | Comment | Organism |
---|---|---|
additional information | the mutant enzyme CFTRG551D, associated with human disease, exhibits defective ATPase activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
ATP | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | apical membrane of epithelia | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Homo sapiens | coupling between ATP hydrolysis and chloride channel gating | ADP + phosphate + open Cl- channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | apical membrane of epithelia | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | chloride channel | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | coupling between ATP hydrolysis and chloride channel gating | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | 60-120 gating events per min | Homo sapiens | |
0.22 | - |
ATP | - |
Homo sapiens |