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Literature summary for 5.6.1.6 extracted from

  • Bear, C.E.; Li, C.; Galley, K.; Wang, Y.; Garami, E.; Ramjeesingh, M.
    Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR (1997), J. Bioenerg. Biomembr., 29, 465-473.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the mutant enzyme CFTRG551D, associated with human disease, exhibits defective ATPase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
ATP
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane apical membrane of epithelia Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens coupling between ATP hydrolysis and chloride channel gating ADP + phosphate + open Cl- channel
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium apical membrane of epithelia Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
?
ATP + H2O + closed Cl- channel coupling between ATP hydrolysis and chloride channel gating Homo sapiens ADP + phosphate + open Cl- channel
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information 60-120 gating events per min Homo sapiens
0.22
-
ATP
-
Homo sapiens