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Literature summary for 5.6.1.6 extracted from

  • Illek, B.; Fischer, H.; Machen, T.E.
    Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3 (1998), Am. J. Physiol., 275, G1221-1226.
    View publication on PubMed
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
1,3-diallyl-8-cyclohexylxanthine
-
 Homo sapiens
3-isobutyl-1-methylxanthine activates Homo sapiens
8-cyclopentyl-1,3-dipropylxanthine activates prephosphorylated CFTR by binding directly to CFTR Homo sapiens
genistein activates prephosphorylated CFTR by binding directly to CFTR, higher concentrations inhibit Homo sapiens
additional information milrinone stimulates CFTR by raising cAMP concentration Homo sapiens
NS-004 activates prephosphorylated CFTR by binding directly to CFTR Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens CFTR appears to be important both as a HCO3- conductance and also in some way as a direct or indirect regulator of adjacent anion exchange, e.g. as a source of luminal Cl- that may exchange for cellular HCO3- and/or as a means of keeping cellular Cl- concentration low enough that the anion exchanger operates as an HCO3- secretion mechanism ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel CFTR appears to be important both as a HCO3- conductance and also in some way as a direct or indirect regulator of adjacent anion exchange, e.g. as a source of luminal Cl- that may exchange for cellular HCO3- and/or as a means of keeping cellular Cl- concentration low enough that the anion exchanger operates as an HCO3- secretion mechanism Homo sapiens ADP + phosphate + open Cl- channel
-
 ?